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Why This Was Ignored • Cataract care became procedure-centric • Redox biology was underestimated • Ayurveda’s preventive logic was sidelined INP reframes cataract as: A failure of lens self-maintenance, not merely aging

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Next-stage research must employ sophisticated in vivo models, such as cell-specific conditional knockout mice (e.g., targeting Igfbp4 in PASMCs or Igfbp7 in endothelial cells), to unequivocally establish causal roles and identify the most therapeutically tractable targets